Non‐autophagic roles of autophagy‐related proteins
Identifieur interne : 001141 ( Main/Exploration ); précédent : 001140; suivant : 001142Non‐autophagic roles of autophagy‐related proteins
Auteurs : Suresh Subramani [États-Unis] ; Vivek Malhotra [Espagne]Source :
- EMBO reports [ 1469-221X ] ; 2013-02.
English descriptors
- Teeft :
- Apoptosis, Atg1, Atg4b, Atg5, Atg7, Atg8, Autophagic, Autophagic machinery, Autophagosomal, Autophagosomal membrane, Autophagosome, Autophagosome formation, Autophagosomes, Autophagy, Autophagy machinery, Autophagy proteins, Axon guidance, Beclin, Biol, Biol cell, Biol chem, Biology organization, Biology organization review function, Caenorhabditis elegans, Caspase, Cell biol, Cell cycle arrest, Cell host microbe, Cell survival, Cellular, Cleavage, Droplet, Embo, Embo reports, Endoplasmic, Endoplasmic reticulum, Exocytosis, Genomic regulation, Hormone secretion, Isolation membrane, Kinase, Lipid, Lipid droplets, Lysosome, Membrane, Neurite outgrowth, Osteoclast, Paneth cells, Pastoris, Pathway, Plasma membrane, Protein, Receptor, Regulator, Replication, Reticulum, Rig1, Secretion, Secretory, Selective autophagy, Snare, Ubiquitin, Ulk1, Unconventional, Unconventional protein secretion, Unconventional secretion, Vacuolar, Vacuole, Vacuole fusion, Vesicle, Viral, Viral replication, Yeast.
Abstract
Autophagy and autophagy‐related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin‐like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non‐autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non‐autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
Autophagy is a key cellular process that involves the degradation of a cell's own components through the lysosome machinery. Recent studies suggest that autophagy proteins can also participate in diverse non‐autophagy‐related cellular processes. This review discusses the growing number of non‐autophagy roles of autophagy‐related proteins.
Url:
DOI: 10.1038/embor.2012.220
Affiliations:
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function</term><term>Caenorhabditis elegans</term><term>Caspase</term><term>Cell biol</term><term>Cell cycle arrest</term><term>Cell host microbe</term><term>Cell survival</term><term>Cellular</term><term>Cleavage</term><term>Droplet</term><term>Embo</term><term>Embo reports</term><term>Endoplasmic</term><term>Endoplasmic reticulum</term><term>Exocytosis</term><term>Genomic regulation</term><term>Hormone secretion</term><term>Isolation membrane</term><term>Kinase</term><term>Lipid</term><term>Lipid droplets</term><term>Lysosome</term><term>Membrane</term><term>Neurite outgrowth</term><term>Osteoclast</term><term>Paneth cells</term><term>Pastoris</term><term>Pathway</term><term>Plasma membrane</term><term>Protein</term><term>Receptor</term><term>Regulator</term><term>Replication</term><term>Reticulum</term><term>Rig1</term><term>Secretion</term><term>Secretory</term><term>Selective autophagy</term><term>Snare</term><term>Ubiquitin</term><term>Ulk1</term><term>Unconventional</term><term>Unconventional protein secretion</term><term>Unconventional secretion</term><term>Vacuolar</term><term>Vacuole</term><term>Vacuole fusion</term><term>Vesicle</term><term>Viral</term><term>Viral replication</term><term>Yeast</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Autophagy and autophagy‐related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin‐like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non‐autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non‐autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.</div><div type="abstract">Autophagy is a key cellular process that involves the degradation of a cell's own components through the lysosome machinery. Recent studies suggest that autophagy proteins can also participate in diverse non‐autophagy‐related cellular processes. This review discusses the growing number of non‐autophagy roles of autophagy‐related proteins.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>San Diego</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Subramani, Suresh" sort="Subramani, Suresh" uniqKey="Subramani S" first="Suresh" last="Subramani">Suresh Subramani</name></region><name sortKey="Subramani, Suresh" sort="Subramani, Suresh" uniqKey="Subramani S" first="Suresh" last="Subramani">Suresh Subramani</name></country><country name="Espagne"><noRegion><name sortKey="Malhotra, Vivek" sort="Malhotra, Vivek" uniqKey="Malhotra V" first="Vivek" last="Malhotra">Vivek Malhotra</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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